Filshtein TJ, et al. - Using Alzheimer's disease [AD] genetic risk scores (AD-GRS), researchers adopted a novel approach to assess the net effect of cognitive reserve, combining both prediagnosis and postdiagnosis risk, on adverse AD-related outcomes. Using 242,959 UK Biobank candidates age 56+ years, whether cognitive reserve (operationalized as education) modified connections between AD-GRS and mortality or hospitalization (total count, fall-related, and urinary tract infection-related) was evaluated. Investigators found that AD-GRS anticipated mortality and outcomes of hospitalization. Education did not alter the effects of AD-GRS on mortality, but had a noticeably worse effect on hospitalizations due to infection of the urinary tract or falling among low-education people than high-education. The study findings suggested that education has not conveyed differential survival benefits to individuals with higher genetic risk of AD, but may lessen the risk of AD genetic risk associated with hospitalization.