Tomlinson SB, et al. - In this retrospective study involving 12 children, researchers investigated the long-term reproducibility of spike propagation patterns over hours to days of interictal recording. According to results, in spike propagation sequences, regions displayed decidedly steady preferences to appear upstream, intermediate, or downstream. Regions involved in seizure generation seemed more upstream in spike propagation sequences at the group level. Findings revealed that interictal spike, which is a characteristic trait of invasive electroencephalography (EEG) recordings in children with refractory epilepsy, propagation is an epileptic network output that is highly reproducible. These findings shed new light on the spatiotemporal dynamics which may restrict the refractory epilepsy network mechanisms.