Ramlogan S, Aly D, France R, et al. - In this prospective study that investigated two-dimensional speckle-tracking strain on two software platforms in 53 children with normal cardiac segmental anatomy and varying function [normal LV function (n = 38) and cardiomyopathy (n = 15)] with an age range of 1 month to 18 years, researchers assessed the intervendor agreement of strain on two generally used analysis platforms in pediatrics by layer of myocardium and data compression. Between two commonly used software platforms, comparison of LV global longitudinal (GLS) and circumferential strain (GCS) following the European Association of Cardiovascular Imaging/American Society of Echocardiography Industry Task Force recommendations illustrated good to excellent agreement in pediatrics, despite the layer of analysis or the image format, however, between vendor platforms, some degree of alterations continues. In all, the GLS agreement was more strong vs GCS, and this variation is amplified in particular subanalyses. Data imply that comparisons of strain values captured on these two vendors would be prudent, although when the indication is the discovery of small deviations between serial echocardiograms, one should be careful.