Haderlein M, et al. - In treatment-naive subjects with synchronous metastatic rectal cancer, researchers assessed the outcome after chemotherapy with FOLFOXIRI, followed by local therapeutic procedures of all tumor lesions. They reviewed data from 30 subjects with synchronous distant metastatic rectal cancer who underwent chemotherapy with FOLFOXIRI and subsequent local therapy in the institution. Even in a subset of patients with unresectable disease at initial diagnosis, response to intensified first-line chemotherapy with FOLFOXIRI, treatment of the primary rectal tumor, and repeated thorough local ablative procedures might lead to long-term survival in patients with synchronous metastasized rectal cancer.