Langner S, et al. – This study was undertaken to investigate a possible correlation between repeated intravenous administration of gadobutrol and increased signal intensity in the grey and white matter using voxel–based whole–brain analysis. The results suggested that voxel–based whole–brain analysis did not demonstrate increased signal intensity of GM and WM on unenhanced T1–weighted images after repeated gadobutrol administration. Moreover, the molecular structure of gadolinium–based contrast agent preparations may be an essential factor causing SI increase on unenhanced T1–weighted images.