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Renal tumours in Australian children: 30 years of incidence, outcome and second primary malignancy data from the Australian Childhood Cancer Registry

Journal of Paediatrics and Child Health Apr 07, 2020

Jones BC, Youlden DR, Cundy TP, et al. - Utilizing national population‐based data from the Australian Childhood Cancer Registry, researchers sought to characterize the incidence and outcomes of childhood renal malignancies in Australia. In addition, details relating to second primary malignancies (SPMs) were analyzed. De‐identified data for children, aged 0 to 14 years, diagnosed with renal malignancies from 1983 to 2015 inclusive have been extracted. Using the cohort method, cause‐specific (CSS) and event‐free survival up to 20 years from diagnosis were estimated. Between 1983 and 2015, 1,046 children in Australia were diagnosed with renal malignancies, creating an annual age‐standardised incidence rate of 8 per million children, which remained constant over the study period. Over the study period, five‐year CSS did not change and was highest for nephroblastoma. Across Australia, children treated for renal malignancies have outstanding long-term survival which has remained constant since 1983. SPMs are rare for childhood renal cancer after treatment but have poor prognosis. Relapse has a similarly poor prognosis of SPM but is more common. Such statistics are comparable to registry outcomes in similarly developed nations.

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