Zhao T, et al. - Authors assessed the fluctuation of serum uric acid (SUA) during acute gout (AG) and explored its potential mechanisms. Data were collected and analyzed from 126 patients diagnosed with gout. In gout patients aged ≤50 years, the level of SUA was significantly higher, inferring that early onset of gout needs to be taken seriously. During acute gouty arthritis, SUA was downregulated, which might be related to an increase in urinary excretion of uric acid. Findings suggested a negative association of serum uric acid with age in gout patients. SUA, creatinine clearance, age, body mass index and urine volume affected the 24-hour uric acid urinary excretion.