Lin J, Tao W, Wei J, et al. - Researchers investigated if renal dysfunction (RD) impacts the diagnostic performance of club cell protein 16 (CC16) for acute respiratory distress syndrome (ARDS) in intensive care unit (ICU) patients. This study involved 479 ICU patients. Based on the diagnoses, participants were grouped as: control, acute kidney injury (AKI), chronic kidney disease (CKD), ARDS, ARDS+AKI, and ARDS+CKD. Via receiver operating characteristic curve analysis, they evaluated sensitivity, specificity, and cutoff values for serum CC16. Findings demonstrated that among ICU patients, the diagnostic specificity, diagnostic cutoff value, as well as predictive value for 7-day mortality of serum CC16 for ARDS was decreased by RD.