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Renal and intestinal excretion of 90Y and 166Ho after transarterial radioembolization of liver tumors

American Journal of Roentgenology Mar 13, 2020

Drescher R, et al. - This study seeks to identify the amount of free radioactivity in renal and intestinal excretions during the first 48 hours after transarterial radioembolization (TARE) procedures on the liver. Researchers obtained urinary, intestinal, and biliary excretions of patients who underwent TARE with three different types of microspheres during a postinterventional period of 48 hours (divided into two 24-hour intervals). They conducted radioactivity measurements. A total of 24 individuals were included, 10 treated with 90Y-glass, 10 with 90Y-resin, and four with 166Ho–poly-L-lactic acid (PLLA) microspheres. Activity excretion occurred in all cases. The study found that renal and intestinal excretion of radioactivity after TARE is low but not negligible. It was demonstrated that the radiation risk for individuals interacting with individuals can be minimized whether contact with urine and bile is avoided, especially during the first 24 hours after the procedure.
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