Marcovecchio ML, et al. - In the present study, researchers ascertained if the top albumin-to-creatinine ratio (ACR) tertile remained linked to diabetic nephropathy (DN) and cardiovascular disease (CVD) risk over the 2–4-year Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT) study. It was observed that the cumulative incidence of microalbuminuria was 16.3% in the high-ACR vs 5.5% in the low-ACR group after a median follow-up of 3.9 years. Results of this study suggested that ACR at the higher end of the normal range at the age of 10–16 years was correlated, independently of HbA1c, with an increased risk of development to microalbuminuria and future CVD risk.