Qin Z, et al. - In 2,312 patients with type 2 diabetes mellitus who had percutaneous coronary intervention for coronary artery disease and who were followed up by angiography, researchers investigated the possible role of remnant lipoproteins-induced atherosclerosis in the incidence and development of in-stent restenosis (ISR). They used multivariate Cox’s proportional hazards regression modelling and performed propensity score matching, resulting in 762 pairs. Findings revealed an independent association of remnant-like particle cholesterol (RLP-C) with ISR. The optimal cutoff point to predict ISR was baseline RLP-C level of 0.505 mmol/L. A significantly higher cumulative rate of ISR was reported for patients with RLP-C levels ≥ 0.505 mmol/L vs patients vs RLP-C levels < 0.505 mmol/L. In diabetic patients, the significance of remnant-like particle cholesterol in cardiovascular pathology was highlighted. In order to better prevent in-stent restenosis in diabetic patients, measures to control RLP-C below 0.505 mmol/L are required.