Molenkamp S, et al. -  This study was undertaken to evaluate the reliability of sonographic measurement of palmar nodules. Researchers evaluated 50 idividuals with nodules characteristic for early disease with ultrasound by 2 observers. This research estimated four different aspects of Dupuytren disease (DD) nodules in the transversal and sagittal planes, width, depth, circumference, and area. Applying the intraclass correlation coefficient , the intra- and interobserver reliabilities were estimated.  They further estimated standard error of measurement and the smallest detectable change for each aspect. They found significant intraobserver reliability of sonographic assessment of DD nodules. The assessment of area is the most reliable and is, thus, considered for future studies. Nevertheless, even single-observer assessments have a clear dispersion, and a variation beyond 16.9 (61%) and 22.2 mm2 (79%) has to be observed in the transverse and sagittal planes, respectively, before it can be recognized as regression or progression.