Sun CJ, Brisson D, Gaudet D, et al. - The present study was performed to correlate the relative impact of the full range of mild, moderate, and severe hypertriglyceridemia (HTG) on the status of non-high density lipoprotein cholesterol (non-HDLC) and apoB as cardiovascular disease (CVD) risk markers. The analysis included the lipid profile data from 4,347 individuals in a Lipid Clinic cohort with baseline fasting lipid profiles documented prior to starting lipid-lowering medications.  Researchers explored the relationship between non-HDLC and apoB in intervals of increasing triglyceride (TG). They examined non-HDLC and apoB at each TG level applying comparative CVD risk equivalent categories, and evaluated for divergence and discordance. The results of this study exhibited that non-HDLC and apoB should not be viewed as interchangeable CVD risk markers in the presence of severe HTG. This has never been investigated. This study's findings demonstrate that discordance between non-HDLC and apoB can cause clinically important divergence in CVD risk categorization, with elevating HTG severity.