Singh RR, et al. - Authors attempted to assess the prevalence of relative adrenal insufficiency (RAI) and its correlation to clinical course in non-septic cirrhosis patients with ascites. Sixty-six consecutive non-septic cirrhosis patients with ascites were included in this investigation. They defined RAI by a delta cortisol lower than 9 μg/dL and/or a peak cortisol lower than 18 μg/dL. A significant correlation of prevalence of RAI with prothrombin time, international normalized ratio, model for end stage liver disease (MELD) scores and Child-Turcotte-Pugh (CTP) class was observed. No association was found between RAI and the risk to develop new infections, severe sepsis, type 1 hepatorenal syndrome (HRS) and death during follow-up. The findings demonstrated that RAI was common in non-septic cirrhotic patients with ascites and its prevalence increases with severity of liver disease, however, it did not affect the short-term outcome in these patients.