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Relationships between clinical presentation, serology, histology, and duodenal deposits of tissue transglutaminase antibodies in pediatric celiac disease

Digestive Diseases Jul 20, 2018

Loberman-Nachum N, et al. - A retrospective single-center, cohort study was performed to investigate associations between symptoms, serum anti-tissue transglutaminase antibodies (tTG) levels, mucosal damage, and mucosal anti-tTG deposits in pediatric celiac disease (CD). Participants in the study were children referred for endoscopy with suspected CD during 2011–2014. In children with CD, multiple symptoms and high serum anti-tTG antibody levels associated with mucosal damage. Researchers found that the role of immunohistochemical staining for intestinal anti-tTG mucosal deposits in the diagnosis of the borderline CD was not yet established.
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