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Relationship of radiation dose to efficacy of radioembolization of liver metastasis from breast cancer

European Journal of Radiology Jan 15, 2021

Ridouani R, Soliman MM, England R, et al. - Following transarterial radioembolization (TARE) of breast cancer liver metastasis, researchers ascertained the association of tumoral and nontumoral radiation dose to response and toxicity. All patients with breast cancer liver metastases treated with TARE between February 2011and June 2019 were evaluated by researchers in this retrospective study. On baseline PET/CT prior to TARE, they evaluated the extent of the disease as unilobar or bilobar, and further evaluated response for targeted regions with modified PERCIST criteria on the first follow-up PET/CT. Sixty patients had a pre-and post-TARE PET/CT among 64 women, of whom 46/60 (77%) achieved an objective response (OR). Higher tumoral radiation dose (>79.5 Gy) was correlated with OR in TARE for breast cancer liver metastasis, which was correlated with longer survival. It was shown that pre-existing liver dysfunction was correlated with hepatotoxicity, which was associated with reduced survival.

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