Zhang Q, et al. - Whether a link exists between left ventricular thrombus (LVT) formation and 1-year major adverse cardio-cerebrovascular events (MACCE) in those with anterior acute ST-segment elevation myocardial infarction (ant-AMI) treated by primary percutaneous coronary intervention (PPCI) was investigated among 1,488 consecutive patients with ant-AMI. LVT was found in 106 (7.1%) patients and 1,382 (92.9%) had no LVT. A higher incidence of MACCE was observed in patients with LVT vs in patients without LVT (21.7% vs 10.3%). Of the individual MACCE components, LVT was found to be only related to incidence of congestive heart failure. LVT was identified as an independent risk factor for MACCE, after adjusting for principal confounders; 24-hour left ventricular ejection fraction, creatine kinase peak value, and age were other independent predictors. Overall, LVT independently predicted 1-year MACCE events in this patient population. MACCE risk may be attenuated and disappearance of thrombus be promoted via treatment with vitamin K antagonist in the therapeutic range.