Ndrepepa G, et al. - In 1,312 patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) between 2002 and 2007, researchers evaluated if left ventricular end-diastolic pressure (LVEDP) had any relationship to myocardial salvage and long-term mortality. At the time of intervention, LVEDP was measured and three groups of patients were defined: LVEDP in the 1st tertile (LVEDP, 4–19 mmHg; n = 496), LVEDP in the 2nd tertile (LVEDP >19–24 mmHg; n = 410) LVEDP in the 3rd tertile (LVEDP >24–45 mmHg; n = 406). The focus was on 8-year cardiac mortality (primary outcome). In 114 patients, occurrence of the primary outcome (cardiac deaths) was reported. In the 1st to 3rd tertiles of LVEDP, occurrence of death was documented in 26 (7.9%), 36 (11.5%), and 52 (16.4%) patients, respectively. Findings revealed that elevated LVEDP correlated with the extent of myocardial ischemia, reduced myocardial salvage and increased risk of 8-year cardiac mortality in STEMI patients.