Relationship of apolipoproteins with subclinical cardiovascular risk in youth
The Journal of Pediatrics Aug 14, 2020
Czeck MA, Northrop EF, Evanoff NG, et al. - This study was conducted on 338 children and adolescents (178 females) with a mean age 13.0 ± 2.8 years, to investigate the link of apolipoproteins with arterial stiffness and carotid artery structure in these populations. Using human apolipoprotein magnetic bead panel, measurements of apolipoproteins (AI, AII, B 100, CII, CIII, and E) were obtained. To assess pulse wave velocity, applanation tonometry was used. Carotid intima-media thickness measurements were obtained via ultrasound imaging. According to findings, increased arterial stiffness was observed in relation to higher levels of apolipoprotein AII, E, and CIII:CII ratio in children and adolescents, both with and without adjusting for percent body fat. The likely usefulness of these specific apolipoproteins was suggested as biomarkers of cardiovascular risk.
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