Zhang R, et al. - In this analysis, demographic data including age, sex, weight, basic clinical information like New York Heart Association (NYHA) class and pathological type were gathered to examine the part B7-H3 plays in the prognosis of congenital heart disease (CHD) in pediatric patients. From August 2011 to December 2012, 65 CHD patients from age 3-12 years who went to the hospital were assessed. Results of this study suggested that B7-H3 could be an independent risk factor for 5-year mortality for these CHD patients. Findings revealed that B7-H3 was up-regulated in dead CHD patients, and serum levels of B7-H3 were associated with long-term major cardiovascular events (MACE) and 5-year mortality of CHD patients.