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Relationship between renal function and blood pressure dipping status in renal transplant recipients: A longitudinal study

BMC Nephrology Oct 06, 2021

Jaques DA, Saudan P, Martinez C, et al. - Improved renal function in kidney transplant (KTX) recipients was evident in the presence of preserved systolic dipping, this was independently of potential confounders, including hypertension (HT) and proteinuria. It is yet to be determined in clinical trials if dipping status alteration by chronotherapy would preserve renal function.

  • This is an analysis of 123 KTX recipients with a mean follow-up of 2.12 ± 0.45 years after ambulatory blood pressure monitoring.

  • A high prevalence of non-dippers was confirmed, with 81 (65.8%) patients being non-dippers.

  • Multivariate analysis showed a positive association of systolic dipping status with estimated glomerular filtration rate (eGFR).

  • In addition, relative to non-dippers, dippers showed a 10.4 mL/min/1.73m 2 higher eGFR.

  • There was a negative correlation of HT with eGFR.

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