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Relationship between preoperative antidepressant and antianxiety medications and postoperative hospital length of stay

Anesthesia & Analgesia Jan 23, 2019

Vashishta R, et al. - Researchers assessed postoperative hospital length of stay in relation to preoperative antidepressants and antianxiety medications, while controlling for confounding variables (age, sex, medical comorbidities, and surgical type), in 48,435 adult patients in an administrative database who had noncardiac surgery from 2011 to 2014 at a single, large urban academic institution. Among participants, 5,111 (10.5%) were on antidepressants and 4,912 (10.1%) on antianxiety medications. They noted that the median length of stay was 3 days (interquartile range = 2–6). After controlling for confounding variables, increased length of stay with an incidence rate ratio of 1.04 (99% confidence interval, 1.0–1.08, P < .001) and antianxiety medication with an incidence rate ratio of 1.1 (99% confidence interval, 1.06–1.14; P < .001) were observed in association with preoperative antidepressant medication, this finding implies a possible need of paying greater attention on these patients during the perioperative period to hasten recovery, which may involve integrating preoperative counseling, postoperative psychiatric consults, or holistic recovery approaches into enhanced recovery protocols.
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