Nakamura M, Kadota K, Takahashi A, et al. - Researchers investigated Japanese patients undergoing percutaneous coronary intervention (PCI), to determine ischemic/bleeding events as well as platelet reactivity in this patient population and they examined links between high/low platelet reactivity and clinical results. For this purpose, they utilized a prospective, multicenter registry, PENDULUM (Platelet Reactivity in Patients with Drug Eluting Stent and Balancing Risk of Bleeding and Ischemic Event), which includes Japanese patients with PCI. At 12 to 48 hours after PCI, measurement of platelet reactivity (P2Y₁₂ reaction unit [PRU] value) was obtained; patients were categorized as having high PRU (> 208), optimal PRU (> 85 to ≤ 208), and low PRU (≤ 85). The high PRU vs the optimal PRU group demonstrated significantly higher major adverse cardiac and cerebrovascular events. The groups did not differ significantly in terms of the incidence of major bleeding. Overall, a link between high platelet reactivity and cardiovascular events was indicated by these real‐world data in Japanese patients undergoing PCI. The trend was shown to be the same in both patients with and those without acute coronary syndrome.