Kou T, et al. - Researchers propose combining neutrophil count (as a marker of inflammation persistence) and high-density lipoprotein cholesterol (HDL-C) (as an anti-atherosclerotic component) into a single biomarker NHR (neutrophils to high density lipoprotein cholesterol ratio) to investigate its correlation with coronary artery disease (CAD) degree as well as predict the severity of coronary stenosis in patients suffering from CAD. Overall 404 eligible patients who received coronary angiography were analyzed. In multiple regression analysis, a significant link of neutrophil HDL-C ratio with CAD was revealed. In receiver operating characteristic (ROC) analysis, 1.51 was the cut-off value for neutrophil HDL-C ratio for CAD prediction with a sensitivity of 94.8% and 0.024 Yoden index, and area under the ROC curve of 0.617. Findings showed a close association of neutrophil HDL-C ratio with coronary artery stenosis, and also revealed neutrophil HDL-C ratio as an independent predictor of severe coronary stenosis.