Sugawara K, Okada Y, Hirota Y, et al. - Researchers here investigated how metformin use affects VB12 status in individuals with type 2 diabetes mellitus in Japan. In this cross‐sectional study, they assessed type 2 diabetes mellitus patients treated (Met group, n = 122) or not treated (control group, n = 63) with metformin. No signficant differences were observed between the control and treated with metformin groups regarding the level of homocysteine, as well as the VB12 level, hemoglobin concentration and mean corpuscular volume. Observations suggest that Japanese type 2 diabetes mellitus patients are at low risk of VB12 deficiency during metformin treatment. However, elderly individuals may exhibit a moderate decrease in the circulating VB12 level, as well as anemia, in correlation with receiving high doses of metformin.