Barchetta I, Cimini FA, Chiappetta C, et al. - In this research, hepatic  angiopoietin‐like proteins (ANGPTLs) and vitamin D receptor (VDR)/VD related gene expression were tested in human obesity in relation to non‐alcoholic fatty liver disease (NAFLD). A cross‐sectional investigation on forty obese individuals with/without NAFLD were performed. Researchers assessed hepatic ANGPTL3, ANGPTL4, ANGPTL8, LPL, VDR, CYP27A1 and CYP2R1 mRNA expression in liver biopsies by RT‐PCR; VDR expression was further evaluated by immunohistochemistry; circulating ANGPTL3 was assessed by Milliplex assay. The outcomes of this study show that hepatic ANGPTL3 expression associates with greater VDR expression, presence and severity of NAFLD and translates in increased circulating ANGPTL3, likely as a outcome of its modulation by up‐regulated hepatic VDR in NAFLD. The data serves new insights to potential mechanisms underlying ANGPTLs–mediated ectopic fat accumulation and NAFLD development in obesity.