Cui L, Lu P, Li S, et al. - Findings demonstrate that high inflammatory levels elevate cognitive impairment risk in hyperhomocysteinemia (HHcy) patients after acute ischemic stroke and transient ischemic attack.

• This study involved 1,466 patients enrolled from a subgroup of China National Stroke Registry-III (CNSR-III) with a median age of 62 (54– 70) years old; 895 (61.05%) had elevated homocysteine levels, 466 (31.79%) had elevated high-sensitivity C-reactive protein (hsCRP) levels, and 755 (51.50%) with post-stroke cognitive impairment (PSCI).

• An association of higher hsCRP levels with cognitive impairment was found in the group of patients with HHcy; this was true whether or not adjusted for multiple potential confounders (crude OR: 1.71; adjusted OR: 1.42).

• In subgroups stratified by age, gender or Trial of Org 10,172 in Acute Stroke Treatment (TOAST) classification, there were no significant interactions for the impact on PSCI.