Relations of arterial stiffness and endothelial dysfunction with incident venous thromboembolism
Thrombosis Research Jun 23, 2021
Ko D, Preis SR, Johnson AD, et al. - This community-based cohort study with robust longitudinal follow-up was attempted to examine the links between comprehensive measures of arterial vascular function and risk of incident venous thromboembolism (VTE). Researchers recorded carotid-femoral pulse wave velocity and central pulse pressure (n = 8,261, age 51.5 ± 15.5 years, 54% females), flow-mediated dilation and hyperemic velocity (n = 6,540, age 47.9 ± 14.1 years, 54% females), and peripheral arterial tonometry ratio (n = 4,998, age 54.3 ± 16.0 years, 52% women) in the Framingham Heart Study Original, Offspring, Third Generation, and Omni cohorts. A mean follow-up of 8.5–11.2 years revealed an incident VTE rate of 1.6–2.1 per 1000 person-years. Findings of this comprehensive analysis revealed that no connection existed between select arterial function measures and risk of VTE post- multivariable adjustment.
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