Unkart JT, Allison MA, Abdelmalek JA, et al. - Given an association between activation of the renin-angiotensin-aldosterone system and cardiovascular disease (CVD) is supported in experimental studies, but the link with subclinical atherosclerosis is uncertain, so, researchers evaluated continuous log-transformed plasma renin activity (PRA) and aldosterone links with the ankle-brachial index (ABI) and coronary artery calcium scores (Agatston) with adjustment for CVD risk factors, kidney function, and inflammatory biomarkers. Participants included 1,699 people without prevalent CVD from the Multi-Ethnic Study of Atherosclerosis. Findings revealed greater burden of subclinical peripheral artery and coronary artery disease in correlation with PRA in a multi-ethnic cohort comprising community-living adults without prevalent clinical CVD. These results afford additional evidence suggestive of the likely deleterious impacts of PRA on cardiovascular health via an atherosclerotic pathway.