Wu L, et al. - In this study including 2264 atrial fibrillation (AF) patients who had computed tomography (CT) to explore the left atrial appendage (LAA) anatomy, researchers evaluated inter-observer and intra-observer agreements in LAA morphology and its real value in stroke prediction. Three reviewers judged the LAA morphology independently. Only in 655 cases (28.9%), including 86 patients with a prior stroke, a consensus between all 3 reviewers was reached. In all the 3 reviewers, poor intra-observer consistency was observed between two times of reading. Prior stroke was reported in relation to persistent AF, female gender and age in multivariate analysis. There was no link between LAA morphology and prior stroke. No increased risk was observed in cases with non-Chicken Wing LAA morphology. Overall, high inter-observer and intra-observer variabilities were seen. This implies the non-reliability of existing classification of LAA morphology.