Shiyovich A, et al. - Researchers performed this inquiry in patients with stable coronary artery disease (CAD) managed with aspirin, to determine the link between high on-aspirin platelet reactivity (HAPR) and albumin levels in these patients. The screening was performed in patients with recognized stable CAD, receiving aspirin (75-100 mg qd) regularly for at least one month. The cases with cancer, sepsis or acute infection, active inflammatory/rheumatic disease, recent major operation, chronic liver failure, treatment with other anti-platelet drugs, non-adherence with aspirin and thrombocytopenia, were removed from the study. This analysis included 116 patients; aged 69 ± 10, 28% were women. Hypoalbuminemic (≤ 3.5 g/dL) were 20 (17%) in total. The hypoalbuminemic group exhibited significantly lower serum albumin levels and significantly higher mean aspirin reaction units than the normal albumin group. HAPR was most strongly predicted by albumin ≤ 3.5 in patients with stable CAD, as revealed in a multivariate analysis adjusted for potential confounders. Overall, findings revealed a strong link of hypoalbuminemia with HAPR in this study population.