Mittnacht J, Choukair D, Breil T, et al. - Researchers conducted this explorative study to assess sequelae of disease and therapy in adolescents with chronic endocrinopathies utilizing a medical and psychological workup to record the health‐related quality of life (HRQoL), near-final height (NFH) and body compositions during the transition period from paediatric to adult care. In 134 patients (70 females and 64 males) from May 2010 to March 2016 diagnosed with congenital adrenal hyperplasia (CAH; n = 22), multiple pituitary hormone deficiency (MPHD; n = 17), growth hormone deficiency (GHD; n = 37), Turner syndrome (TS; n = 27), SGA‐short stature (SGA; n = 20) and Klinefelter syndrome (KS; n = 11), NFH, weight, BMI, grip strength (GS), hip and waist circumference (HC; WC), skin folds (SF) and HRQoL T‐scores by KIDSCREEN and DISABKIDS have been evaluated. According to findings, HRQoL and body compositions were comparable to those of healthy adolescents. Lower scores in HRQoL dimensions as self‐perception, physical well‐being, social exclusion and emotions have been identified and negatively correlated with BMI. Treatment approaches and psychological help should consider HRQoL and adapted in specific treatment guidelines.