Chamberlain AM, et al. - Among patients on moderate to high-intensity statins for atherosclerotic cardiovascular disease (ASCVD), the link between low-density lipoprotein cholesterol (LDL-C) level and subsequent cardiovascular events and deaths was assessed using Cox regression models. Participants were those with a prescription for a moderate- or high-intensity statin and an LDL-C measurement in the 90 days after index ASCVD (myocardial infarction, unstable angina, coronary revascularization, ischemic stroke/transient ischemic attack). Follow up was of a median of 5.9 years. From index ASCVD through follow-up, 1,241 events in 1,854 patients (mean (SD) age 66.0 (13.3) years, 63.6% male) were documented. A high rate of occurrence of subsequent cardiovascular events was reported in patients with ASCVD. Those with LDL-C ≥100 mg/dL had the highest rates. This was suggestive of unmet treatment needs even in patients receiving moderate- to high-intensity statins.