Versluis A, Knulst AC, van Erp FC, et al. - Given the reintroduction of food following negative food challenge (FC) encounters many hindrances, researchers determined the frequency, causes as well as risk factors of reintroduction failure in adults in this prospective analysis. Participants, ie, adult patients were provided with standardized follow-up care following negative FCs including a reintroduction scheme and supportive telephone consultations. There were 80 patients, with 113 negative FCs. Findings revealed frequent reintroduction failure after negative FCs in adults. Also, experts noted reintroduction failure increased over time and was mainly attributable to atypical symptoms. For long-term reintroduction failure, the following five risk factors were identified: if culprit food was not one of the 13 EU regulated allergens, reintroduction failure at short-term, atypical symptoms during FC, lower quality of life and higher state anxiety. There is a requirement for more patient-tailored care prior to and following negative FCs.