Riemann CD, et al. - Researchers evaluated the impacts of fluocinolone acetonide implant (FAc) on diabetic macular edema (DME) retinal thickness fluctuations, via this post-hoc chart review of the real-world USER study. Participants were patients receiving 0.2 μg/day FAc implant. Before and after FAc implant, the percentage of eyes with central subfield thickness (CST) of 300 µm or less were compared; analysis of mean retinal thickness amplitude (RTA), retinal thickness standard deviation (RTSD), and two case studies was done. The patients who presented were 130 in total, with mean age of 69.6 years; CST was available for 120 of 160 treated eyes. Findings revealed significant decline in retinal thickness fluctuations post-FAc, and these were shown to be correlated with improvement in visual acuity (VA). A more close correlation of both RTSD and RTA measures to last noted VA vs area under the CST-time curve itself was revealed.