Dhar R, Chen Y, Hamzehloo A, et al. – Researchers enrolled participants in a stroke cohort study who presented within 6 hours of onset and had baseline and ≥ 1 follow-up brain CT scans available to examine displacement of cerebrospinal fluid (ΔCSF) as a dynamic quantitative imaging biomarker of edema formation. Serial imaging in 738 patients with stroke, of whom 91 acquired cerebral edema with midline shift (MLS) were pooled. Of early edema formation, CSF volumetrics offered a quantitative assessment. Moreover, for the development of MLS and more unfavorable neurological outcome, ΔCSF from baseline to 24-hour CT seemed like a promising early biomarker.