McCall WV, Benca RM, Rosenquist PB, et al. - Researchers compared the efficacy of targeted treatment of insomnia with controlled-release zolpidem (zolpidem-CR) vs placebo in reducing suicidal ideation among suicidal adults with insomnia via performing Reducing Suicidal Ideation Through Insomnia Treatment, an 8-week three-site double-blind placebo-controlled parallel-group randomized controlled trial. Random assignment of a total of 103 participants to receive zolpidem-CR (N = 51) or placebo (N = 52) (64 women and 39 men; mean age = 40.5 years) was performed. Outcomes suggest that suicidal outpatients, especially patients with severe insomnia, may benefit from co-prescription of a hypnotic during initiation of an antidepressant although no evidence supported the routine prescription of hypnotic medication for mitigating suicidal ideation in all depressed outpatients with insomnia.