Donnellan A, et al. - In a quality improvement project, using statistical process control methodology, researchers assessed how infusion rates of opioids and benzodiazepines in postneonatal postoperative pediatric cardiac surgery patients could be influenced by the implementation of a comfort algorithm. This study was conducted in 25-bed tertiary care pediatric cardiac ICU in an urban academic Children’s hospital. A guided comfort medication algorithm was implemented, with key components; a low dose opioid continuous infusion, judicious use of frequent as needed opioids, initiation of dexmedetomidine infusion postoperatively, and minimal use of benzodiazepines. They found that without compromising safety, opioid and benzodiazepine dosing were reduced by the implementation of a pediatric comfort algorithm.