Canty E, Carnahan B, Curley T, et al. - Researchers aimed at determining the clinical implications of reduced vancomycin susceptibility (RVS) among pediatric Staphylococcus aureus bloodstream infections. At two children’s hospitals, children with ≥ 1 blood culture positive for S. aureus were identified. Wilcoxon rank-sum and chi-squared tests were used to compare patient and clinical factors for RVS and non-RVS infections. Presence of RVS was noted in 72% (309/426) of cases. Patient or infection characteristics, including methicillin resistance, were not identified to be linked with RVS. Observations overall suggested common occurrence of RVS and its association with a longer duration of bacteremia but not with treatment failure. Frequency of treatment failure was higher for MRSA vs MSSA bloodstream infections. Increase in the odds of treatment failure was observed in correlation with providing empiric vancomycin monotherapy for MRSA infections.