Wang P, et al. - In this prospective cohort study, the researchers examined the relationship of first trimester irisin concentrations and the subsequent development of gestational diabetes mellitus (GDM). From July 2015 to June 2016, this investigation was conducted at three-maternity-centers in China. They gathered and analyzed data for fasting plasma glucose (FPG) and irisin concentrations in the first trimester and one-step GDM screening with 75-g oral glucose tolerance test (OGTT) performed between 24 and 28 weeks of gestation. Results of this study suggested that reduced plasma levels of irisin in first trimester was linked with the increased risk of GDM and could be helpful in identifying women at risk for GDM for early prevention strategies.