Guemes-Villahoz N, Burgos-Blasco B, Vidal-Villegas B, et al. - In this cross-sectional case–control study, researchers sought to assess vessel density (VD) and perfusion density (PD) by optical coherence tomography angiography (OCTA) in COVID-19 patients and to compare the findings with healthy controls, as well as to determine whether there are differences in OCTA parameters between COVID-19 patients with and without associated thrombotic events (TE). The sample consisted of patients with the laboratory-confirmed diagnosis of COVID-19 with and without TE-related to the infection and age-matched healthy controls. Ninety patients were involved, 19 COVID-19 patients with associated TE, 47 COVID-19 patients without TE, and 29 healthy controls. OCTA is a promising tool for assessing microvascular changes in COVID-19 in vivo. Patients infected with SARS-CoV-2 have lower VD and PD than healthy controls. When considering TE, however, no differences were found between COVID-19. Prospective research is needed to further assess the retinal microvascular involvement of SARS-CoV-2 and its influence on the vasculature of other organs.