Chen YS, et al. - The structural changes of the brain that correlate with physical frailty and cognitive impairments in Parkinson’s disease (PD) patients were investigated. For this purpose, researchers performed a frailty assessment using Fried’s criteria and comprehensive neuropsychological testing using the Wechsler Adult Intelligence Scale-III and Cognitive Ability Screening Instrument, in 61 PD patients and 59 age- and sex-matched healthy controls. In addition, they acquired structural brain MR images for voxel-based morphometric analysis. As per outcomes, PD patients display an association of reduced gray matter volume in the lateral occipital cortex with cognitive impairment and physical frailty.