Loeb FF, et al. - The researchers investigated the neural correlates of working memory (WM) in childhood-onset schizophrenia (COS). They revealed that reduced functional activation and connectivity in the WM network in COS supported pathophysiologic continuity with adult-onset schizophrenia (AOS). The low participation rate and accuracy of the patients underscored the disease severity of COS. Hypo-activations and hypo-connectivity were shared by siblings of patients with COS, implying COS as a potential endophenotype.