Gai ND, et al. - The physicians conducted this work to evaluate interleaved blip-up, blip-down non-segmented 3D echo planar imaging (EPI) with pseudo-continuous arterial spin labeling (pCASL) and post-processing for reduced susceptibility artifact cerebral blood flow (CBF) maps. The obtained data indicates that pseudo-continuous arterial spin labeling with non-segmented 3D EPI acquisition applying alternating blip-reversed k-space traversal and distortion correction provided significantly better matching gray matter (GM) CBF maps. Moreover, employing alternating blip-reversed acquisitions during pseudo-continuous arterial spin labeling acquisition resulted in statistically significant improvement over corrected blip-up and blip-down cerebral blood flow (CBF) maps.