AuthorLastNameFI et al. – Outcome data comparing patients with multiple primary invasive cutaneous malignant melanomas (MPMs) to single primary invasive cutaneous malignant melanoma (SPM) are conflicting. In the current study it was shown that MPM patients had a worse outcome than SPM patients.

Methods

• 27,235 patients were identified with a first invasive cutaneous malignant melanoma (CMM).

Results

• 700 patients developed MPMs.
• An interval of less than or equal to 5 years between CMM diagnosis was correlated with decreased CMM-specific survival in stage I-II MPM- versus SPM-patients (HR = 1.32).
• MPM-patients with a longer time interval between diagnoses had a similar risk of CMM-death as SPM-patients.
• The risk of CMM-death increased by nearly 50% above the expected outcome according to stage of the index CMM by the diagnosis of a second CMM (HR = 1.48).