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Reduced ADAMTS13 activity during TTP remission is associated with stroke in TTP survivors

Blood Aug 28, 2019

Upreti H, Kasmani J, Dane K, et al. - Following recovery from acute thrombotic thrombocytopenic purpura (TTP), researchers investigated the incidence as well as the prevalence of stroke in this retrospective-prospective cohort study. They also inquired whether an increased risk for stroke during remission can be seen in relation to lower ADAMTS13 activity following recovery from TTP. After recovery from acute TTP, the occurrence of stroke was reported in 0% patients with normal remission ADAMTS13 activity (greater that 70%) and in 27.6% patients with low ADAMTS13 activity (less than or equal to 70%). Overall, a common prevalence of stroke following recovery from TTP as well as its link with reduced ADAMTS13 activity during remission was shown in this study.

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