Popescu F, et al. - Researchers assessed if the addition of 24-chromosome microarray analysis on miscarriage tissue combined with the standard American Society for Reproductive Medicine (ASRM) evaluation for recurrent miscarriage would explain most losses. They observed that evaluation of products of conception (POC) using 24-chromosome microarray analysis adds significantly to the ASRM recommended evaluation of recurrent pregnancy loss (RPL). All couples with two or more consecutive pregnancy losses should be offered genetic evaluation on miscarriage tissue obtained at the time of the second and subsequent pregnancy losses. In over 90% of miscarriages, the combination of a genetic evaluation on miscarriage tissue with an evidence-based evaluation for RPL would identify a probable or definitive cause.