Sessler DI, Pei L, Huang Y, et al. - In this randomized controlled trial at 13 hospitals in Argentina, Austria, China, Germany, Ireland, New Zealand, Singapore, and the USA of 2,132 women (age < 85 years) having potentially curative primary breast cancer resections, experts ascertained whether breast cancer recurrence following potentially curative surgery was lower with regional anesthesia-analgesia using paravertebral blocks and the anesthetic propofol compared with, with general anesthesia with the volatile anesthetic sevoflurane and opioid analgesia. and if regional anesthesia-analgesia decreased constant incisional pain. In this study population, it was discovered that in comparison with volatile anesthesia (sevoflurane) and opioids, regional anesthesia-analgesia (paravertebral block and propofol) did not decrease breast cancer recurrence following potentially curative surgery. Moreover, the anesthetic technique could not impact the number and severity of constant incisional breast pain. Thus, relative to breast cancer recurrence and constant incisional pain, clinicians could use regional or general anesthesia.