Gulati R, et al. - This paper contemplated if the impact of screening on prostate cancer mortality relative to no screening varied between the European Randomized Study of Screening for Prostate Cancer (ERSPC) and Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO). Taking into consideration the variations in implementation and settings, the ERSPC and PLCO yielded compatible evidence that screening caused a reduction in the prostate cancer mortality.