Shi JH, et al. - Researchers focused on human epidermal growth factor receptor 2 (HER2) expression as well as its significance in postoperative tumor recurrence in hepatocellular carcinoma (HCC). For this purpose, they analyzed clinical and mRNA data of HCC patients from TCGA HCC cohort, GSE89377 and GSE115018. They also assessed HCC biology, including cell survival, proliferation, and epithelial-to-mesenchymal transition (EMT) phenotypes in HepG2, JM1, HER2-transfected McA cells, and transforming growth factor beta (TGF-β); cocultured JM1 cells. HCC datasets demonstrated ERBB2 mRNA amplification and downregulation in its expression was noted in high-grade HCC with worse overall survival. In H4IIE, HepG2, JM1 cells, and 82% (14/17) HCC samples, overexpression of HER2 was observed. There was a correlation of tumor stage with the expression of HER2, E-cadherin, and Vimentin. Via β-catenin and SMAD3, the transforming function of HER2 was found more relevant. In order to suppress the HER2-mediated tumor growth during postoperative liver regeneration, HER2-targeted treatment was recommended.